Direct thrombin Inhibitors and its classification

Bivalent DTIs - bind both to catalytic or active site and also to substrate recognition sites

• Hirudin
• Bivaliridin
• Lepirudin
• Desirudin

Univalent DTIs - bind only to active site

• Argatroban
• Melagatran (and its prodrug ximelagatran)
• Dabigatran

Oral DTIs

• Ximelagatran
• Dabigatran

Parenteral DTIs

• Hirudin
• Bivaliridin
• Lepirudin
• Argatroban